Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Perfusion changes in the white matter of the brain in multiple sclerosis according to MRI data

Authors: Vasilkiv L.M.1 3, Stankevich Yu.A.1 3, Bogomyakova O.B.1 3, Korobko D.S.1 2, Malkova N.A.1 2, Tulupov A.A.1 3

Company:
1 The Institute “International Tomography Center” of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
2 Novosibirsk Regional Center of Multiple Sclerosis and other Autoimmune Diseases of the Nervous System of Novosibirsk State Regional Clinical Hospital, Novosibirsk, Russian Federation
3 Novosibirsk National Research State University, Novosibirsk, Russian Federation

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DOI: https://doi.org/10.24022/1814-6910-2024-21-2-117-126

UDC: 616.832-004.2-073.756.8

Link: Clinical Physiology of Blood Circulaiton. 2024; 21 (2): 117-126

Quote as: Vasilkiv L.M., Stankevich Yu.A., Bogomyakova O.B., Korobko D.S., Malkova N.A., Tulupov A.A. Perfusion changes in the white matter of the brain in multiple sclerosis according to MRI data. Clinical Physiology of Circulation. 2024; 21 (2): 117–126 (in Russ.). DOI: 10.24022/1814-6910-2024-21-2-117-126

Received / Accepted:  03.06.2024 / 20.06.2024

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Abstract

Multiple sclerosis is one of the common demyelinating diseases, characterized by multifocal symptoms. Currently, there is a discussion about the participation of vascular changes in the formation of neurological disorders. The dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) technique allows one to evaluate hemodynamics at the capillary level in vivo.

Objective. To evaluate changes in blood flow at the microcirculatory level in multiple sclerosis using the DSC-technique. Materials and methods. The MR study was carried out on a super-high-angle MR-scanner “Ingenia” (“Philips”) 3 Tesla. The study included 30 healthy volunteers, 71 patients with multiple sclerosis aged 18 to 48 years (mean age was 34.6 ± 8.02 years) and 9 patients with clinically isolated syndrome aged 24 to 38 years (mean age was 29 ± 5.7 years). Quantitative and qualitative assessment of perfusion parameters in demyelination foci and normal-appearing white matter (NAWM) was performed.

Results. Quantitative assessment of perfusion in the NAWM in all groups showed a significant decrease in the cerebral blood flow velocity and volume by 14% and 7%, respectively, starting with a сlinically isolated syndrome and with an increase in the severity of these changes as the disease progresses. Changes in perfusion in demyelination foci are a dynamic process depending on the stage of evolution of demyelination foci.

Conclusion. Assessment of cerebral perfusion allows us to take a new look at the role of the vascular component in the process of formation of focal inflammatory changes in the brain in MS, which can determine a new direction for pathogenetic treatment.

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About Authors

  • Lyubov M. Vasilkiv, Cand. Med. Sci., Radiologist, Senior Researcher at the Neuroscience Laboratory; orcid.org/0000-0003-1838-8130, e-mail: vasilkiv@tomo.nsc.ru
  • Yuliya A. Stankevich, Cand. Med. Sci., Radiologist, Senior Researcher at the Neuroscience Laboratory; orcid.org/0000-0002-7959-5160
  • Olga B. Bogomyakova, Cand. Med. Sci., Radiologist, Researcher at the Laboratory “MRT Technologies”; orcid.org/0000-0002-8880-100X
  • Denis S. Korobko, Cand. Med. Sci., Neurologist, Head of the Novosibirsk Regional Center for Multiple Sclerosis and Other Autoimmune Diseases of the Nervous System; Senior Researcher of the Neuroscience Laboratory; orcid.org/000-0002-7938-3782
  • Nadezhda A. Malkova, Dr. Med. Sci., Neurologist, Curator at the Novosibirsk Regional Center of Multiple Sclerosis and other Autoimmune Diseases; Leading Researcher of the Neuroscience Laboratory; orcid.org/0000-0002-1255-8525
  • Andrey A. Tulupov, Dr. Med. Sci., Professor, Corresponding Member of Russian Academy of Sciences, Radiologist, Head of the Laboratory «MRT Technologies», Chief Researcher at the Neuroscience Laboratory; orcid.org/0000-0002-1277-4113

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