Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2025; 22 (1): 1-114 ➤ Коморбидные состояния при ишемической болезни сердца: патогенетические взаимосвязи, клинические риски и последствия

Comorbid conditions in ischemic heart disease: pathogenetic interconnections, clinical risks, and consequences K

Authors: Mamalyga M.L.

Company:
Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2025-22-1-5-20

UDC: 616.12-008.46

Link: Clinical Physiology of Blood Circulaiton. 2025; 22 (1): 5-20

Quote as: Mamalyga M.L. Comorbid conditions in ischemic heart disease: pathogenetic interconnections, clinical risks, and consequences. Clinical Physiology of Circulation. 2025; 22 (1): 5–20 (in Russ.). DOI: 10.24022/1814-6910-2025-22-1-5-20

Keywords:  comorbidity coronary heart disease pathogenetic mechanisms diabetes mellitus chronic kidney disease chronic obstructive pulmonary disease hypothyroidism obstructive sleep apnea syndrome depression

Received / Accepted:  21.01.2025 / 31.01.2025

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Abstract

The review presents a detailed analysis of the results of clinical studies devoted to the study of the pathogenetic mechanisms underlying the relationship between congenital heart disease (CHD) and comorbid conditions, which currently remain largely poorly understood. The publication is aimed at informing practitioners about the features of the manifestation of comorbid disorders in CHD, as well as about the mechanisms of development that provoke them. The relevance of the problem is obvious, but many aspects of the relationship between CHD and comorbid conditions require further fundamental study, which is necessary for the development and implementation of innovative methods of diagnosis and treatment of diseases. When planning a strategy for the treatment of CHD and prescribing cardiotherapy, it is important to take into account that elderly patients are most at risk of developing comorbid diseases, in which the predisposition to cardiovascular diseases increases with age, which is aggravated by the presence of concomitant pathologies. Systematic analysis of research is aimed at developing a holistic understanding of the pathological mechanisms underlying the relationship between CHD and comorbid conditions. The results of the study are intended to contribute to the development of new strategies for timely diagnosis, prevention and personalized treatment of such patients. This is especially important for optimizing clinical outcomes and improving the quality of life of patients suffering from complex forms of cardiovascular diseases.

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  7. Guzik T.J., Touyz R.M. Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension. 2017; 70 (4): 660–667. DOI: 10.1161/HYPERTENSIONAHA.117.07802
  8. Arnett D.K., Blumenthal R.S., Albert M.A., Buroker A.B., Goldberger Z.D., Hahn E.J., Ziaeian B. ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J. Am. Coll. Cardiol. 2019; 74 (10): e177–e232. DOI: 10.1016/j.jacc.2019.03.010
  9. Low Wang C.C., Hess C.N., Hiatt W.R., Goldfine A.B. Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus – mechanisms, management, and clinical considerations. Circulation. 2021; 133 (24): 2459–2502. DOI: 10.1161/CIRCULATIONAHA.116.022194
  10. Libby P. Inflammation and cardiovascular disease mechanisms. Am. J. Clin. Nutr. 2006; 83 (2): 456S–460S. DOI: 10.1093/ajcn/83.2.456S
  11. Jia G., Hill M.A., Sowers J.R. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ. Res. 2018; 122 (4): 624–638. DOI: 10.1161/CIRCRESAHA.117.311586
  12. Ginsberg H.N., Packard C.J., Chapman M.J., Borén J., Aguilar-Salinas C.A., Averna M., Tokgözoğlu L. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies – a consensus statement from the European Atherosclerosis Society. Eur. Heart J. 2021; 42 (47): 4791–4806. DOI: 10.1093/eurheartj/ehab551
  13. Libby P., Ridker P.M., Hansson G.K. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011; 473 (7347): 317–325. DOI: 10.1038/nature10146
  14. Tousoulis D., Oikonomou E., Economou E.K., Crea F., Kaski J.C. Inflammatory cytokines in atherosclerosis: current therapeutic approaches. Eur. Heart J. 2016; 37 (22): 1723–1732. DOI: 10.1093/eurheartj/ehv759
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  16. Seferović P.M., Petrie M.C., Filippatos G.S., Anker S.D., Rosano G., Bauersachs J., Coats A.J. Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur. J. Heart Fail. 2018; 20(5): 853–872. DOI: 10.1002/ejhf.1170
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About Authors

Maksim L. Mamalyga, Dr. Med. Sci., Leading Researcher; ORCID

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