Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Мозговой натрийуретический пептид в диагностике развития осложнений после операции коррекции клапанных пороков сердца и реваскуляризации миокарда

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Link: Clinical Physiology of Blood Circulaiton. 2011; (): -

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Abstract

It was shown that the determination of the level of brain natriuretic peptide (BNP) independently from other diagnostic and prognostic factors may provide additional information in determining the severity of heart failure, prediction of postoperative course in patients with valvular heart disease and coronary heart disease. The level of BNP also predicted the development of adverse cardiovascular events in patients with heart defects. The study included 95 patients (54 patients with various valvular heart disease - the 1st group and 41 patients with coronary artery disease - the 2nd group). 36 (66,7%) patients in the 1st group was performed correction of heart defects, 35 (85,4%) patients with coronary artery disease was performed myocardial revascularization. In patients with valvular heart disease the level of BNP before surgery with a high probability to predict the development of cardiac complications: acute heart failure, atrial fibrillation and ventricular arrhythmias in the early postoperative period. In patients with coronary artery disease the level of BNP before surgery significantly predicted the development of only ventricular arrhythmias in the early postoperative period. Level of BNP at admission to the hospital more than 1120.68 pg/ml, with a high probability to predict the development of fatal outcome in operated as well as in non-operated patients with valvular heart disease

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