Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


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Authors: L.A. Bockeria, V.A. Lisсhouk, D.Sh. Gazizova, L.V. Sazykina, A.V. Sobolev, A.N. Makhmudova, N.N. Koloskova

Company:
A.N. Bakoulev Scientific Center for Cardiovascular Surgery, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

Link: Clinical Physiology of Blood Circulaiton. 2015; (): -

Quote as: Bockeria L.A., Lisсhouk V.A., Gazizova D.Sh., Sazykina L.V., Sobolev A.V., Makhmudova A.N., Koloskova N.N.. Cardiovascular system regulation concept – from functions control to coordination of opportunities. Part 6. Role of load of the left and right ventricles of heart. Klinicheskaya Fiziologiya Krovoobrashcheniya (Clinical Physiology of Circulation, Russian journal). 2015; 1: 19-29 (in Russ.)

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Abstract

Objective. To estimate load of the left and right ventricles of heart of patients with of dilated cardiomyopathy (DСM) in the Genesis of the disease.

Material and methods. The analysis of power of ventricles of heart of 95 patients with DCM is carried out. Two groups of patients are allocated. The first group included 46 patients with the cardiac index (CI) above an average in comparison with all surveyed, the second – 49 patients with CI below average value. Computer monitoring, statistical and simulation analysis of function and properties were used.

Results. Indexes of power of the left and right ventricles of heart of all surveyed patients don't derate dispersion of indexes of power of healthy adults in rest: for the left ventricle 0,43–0,97 and for the right 0,06–0,18 W/m2. The index of power of the left ventricle in group 2 is 42% lower; than patients have groups 1. The index of power of the right ventricle in group 2 is 30% lower, than patients have groups 1. The coefficient of a variation of an index of power of the left ventricle of all surveyed sick 35,5% also was defined by a CI variation on 29,8% and the arterial pressure (AP) upon 14,0%. The variation of an index of power of the right ventricle of all sick 44,6% also was defined by pressure fluctuations in a pulmonary artery (PAP) on 40,9%. Changes of power of the left ventricle of all surveyed patients are closely connected with CI changes (coefficient of correlation 0,92) and is less close with changes the AP (0,47). In group of 1 change of power of the left ventricle are closely connected, as with CI changes – 0,85 and the AP – 0,72. And in group 2 the relationship with CI is reduced, but remains quite high (0,68), and the relationship with AP decreases (0,48). Changes of power of the right ventricle of all surveyed patients, as well as in groups 1 and 2, are connected with CI much more weakly, than it takes place for the left ventricle (0,36, -0,08 and 0,31, respectively) and is close with changes of pulmonary arterial pressure (coefficients of correlation 0,76, 0,93 and 0,88, respectively).

Conclusion. Changes of power of ventricles of heart of all surveyed patients don't leave a dispersion framework for healthy adults in rest. At patients with CI is higher, than at healthy people, load of the left heart is defined by change of warm emission and arterial pressure. Changes of power of the right heart, poorly depends on changes of a warm index. As the CI at patients with DCM varies to 30%, and the power of the right ventricle doesn't change, there is a regulatory mechanism changing pressure in a pulmonary artery almost in proportion, but is opposite to CI change.


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