Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Evaluation of the prognostic value of indices of longitudinaldeformation of the left ventricular myocardium after surgicalrevascularization in patients with severe ischemic myocardial dysfunction

Authors: Ya.B. Brand 1, N.M. Bikbova 1, I.V. Klyuchnikov 2, N.I. Kharitonova 1, M.Kh. Mazanov 1, M.A. Sagirov 1, M.G. Ivanov 1

Company:
1 N.V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Department of Health, Bol'shaya Sukharevskaya Ploshchad', 3, Moscow, 129090, Russian Federation
2 Bakoulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2018-15-3-190-197 © Коллектив авторов, 2018 Оригинальная статья УДК 616.127:616.124.2]-007.2:616.127-005.4-089.844-037 Original article

UDC: 616.127:616.124.2]-007.2:616.127-005.4-089.844-037

Link: Clinical Physiology of Blood Circulaiton. 2018; 15 (3): 190-197

Quote as: Brand Ya.B., Bikbova N.M., Klyuchnikov I.V., Kharitonova N.I., Mazanov M.Kh., Sagirov M.A., Ivanov M.G. Evaluation of the prognostic value of indices of longitudinal deformation of the left ventricular myocardium after surgical revascularization in patients with severe ischemic myocardial dysfunction. Clinical Physiology of Circulation. 2018; 15 (3): 190–7 (in Russ.). DOI: 10.24022/1814-6910-2018-15-3-190-197

Received / Accepted:  06.08.2018/17.09.2018

Download
Full text:  

Abstract

Objective. To evaluate the prognostic significance of the indices of longitudinal deformation of the myocardium in patients with coronary artery disease with severe ischemic myocardial dysfunction of the left ventricle based on the analysis of their dynamics before and after revascularization.

Material and methods. 45 male patients with multivessel disease were enrolled in study. All patients underwent standard echocardiography and speckle tracking echocardiography to evaluate the longitudinal left ventricular (LV) myocardial deformation, as well as to assess the symptoms of chronic heart failure (CHF), according to the NYHA classification before and 6 months after the CABG surgery.

Results. Six months after the surgery all patients had correlations of the baseline indices of the longitudinal LV myocardial deformation and the trends of CHF symptoms after the syrgery. If the baseline global longitudinal deformation was less than –6.3%, there was a lack of significant positive trends in CHF symptoms in the postoperative period.

Conclusions. Longitudinal systolic left ventricular myocardial deformation is a reliable quantitative measure of the LV systolic function. The speckle-tracking echocardiography can be used to determine if surgical revascularization is suitable in patients with coronary heart disease and low left LV ejection fraction.

References

  1. Bax J.J., van der Wall E.E., Harbinson M. Radionuclide techniques for the assessment of myocardial viability and hibernation. Heart. 2004; 90 (Suppl. 5): v26–v33. DOI: 10.1136/hrt.2002.007575
  2. Gheorghiade M., Bonow R.O. Chronic heart failure in the United States: a manifestation of coronary artery disease. Circulation. 1998; 97 (3): 282–9. PMID: 9462531
  3. Allman K.C., Shaw L.J., Hachamovitch R., Udelson J.E. Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J. Am. Coll. Cardiol. 2002; 39 (7): 1159–62. PMID: 11923039
  4. Bax J.J., Poldermans D., Elhendy A., Cornel J.H., Boersma E., Rambaldi R. et al. Improvement of left ventricular ejection fraction, heart failure symptoms and prognosis after revascularization in patients with chronic coronary artery disease and viable myocardium detected by dobutamine stress echocardiography. J. Am. Coll. Cardiol. 1999; 34 (1): 163–9. PMID: 10400006
  5. Ascione R., Narayan P., Rogers C.A., Lim K.H.H., Capoun R., Angelini G.D. Early and mid term out come in patients with severe left ventricular dysfunction undergoing coronary artery surgery. Ann. Thorac. Surg. 2003; 76 (3): 793–9. DOI: 10.1016/S0003-4975(03)00664-7
  6. Trachiotis G.D., Weintraub W.S., Johnston T.S., Jones E.L., Guyton R.A., Craver J.M. Coronary artery bypass grafting in patients with advanced left ventricular dysfunction. Ann. Thorac. Surg. 1998; 66 (5): 1632–9. PMID: 9875763
  7. Baker D.W., Jones R., Hodges J., Massie B.M., Konstam M.A., Rose E.A. Management of heart failure: the role of revascularization in the treatment of patients with moderate or severe left ventricular systolic dysfunction. JAMA. 1994; 272 (19): 1528–34. PMID: 7966846
  8. Topkara V., Cheema F.H., Kesavaramanujam S., Mercando M.L., Cheema A.F., Namerow P.B. et al. Coronary artery bypass grafting in patients with low ejection fraction. Circulation. 2005; 112 (9 Suppl): I344–50. DOI: 10.1161/CIRCULATIONAHA.104.526277
  9. Hillis G.S., Zehr K.J., Williams A.W., Schaff H.V., Orzulak T.A., Daly R.C. et al. Outcome of patients with low ejection fraction undergoing coronary artery bypass grafting: renal function and mortality after 3.8 years. Circulation. 2006; 114 (1 Suppl): I414–9. DOI: 10.1161/CIRCULATIONAHA.105.000661
  10. Shapira O.M., Hunter C.T., Anter E., Bao Y., DeAndrade K., Lazar H.L. et al. Coronary artery bypass grafting in patients with severe left ventricular dysfunction – early and mid-term outcomes. J. Card. Surg. 2006; 21 (3): 225–32. DOI: 10.1111/j.1540-8191.2006.00221.x
  11. Scott S.M., Deupree R.H., Sharma G.V., Luchi R.J. A study of unstable angina: 10 year study shows duration of surgical advantage for patients with impaired ejection fraction. Circulation. 1994; 90 (5 Pt 2): II102–3. PMID: 7955237
  12. Lam C.S., Donal E., Kraigher-Krainer E., Vasan R.S. Epidemiology and clinical course of heart failure with preserved ejection fraction. Eur. J. Heart Fail. 2011; 13: 18–28. DOI: 10.1093/eurjhf/hfq121
  13. Attaran S., Shaw M., Bond L., Pullan M.D., Fabri B.M. Does off-pump coronary artery revascularization improve the long term survival in patients with ventricular dysfunction? Interact. Cardiovasc. Thorac. Surg. 2010; 11 (4): 442–6. DOI: 10.1510/icvts.2010.237040
  14. Kunadian V., Zaman A., Qiu W. Revascularization among patients with severe left ventricular dysfunction: a meta-analysis of observational studies. Eur. J. Heart Fail. 2011; 13 (7): 773–84. DOI: 10.1093/eurjhf/hfr037
  15. Teske A.J., De Boeck B.W.L., Melman P.G., Sieswerda G.T., Doevendans P. A., Cramer M.J.M. Echocardiographic quantification of myocardial function using tissue deformation imaging, a guide to image acquisition and analysis using tissue Doppler and speckle tracking. Cardiovasc. Ultrasound. 2007; 5: 27. DOI: 10.1186/1476-7120-5-27
  16. Shimoni S., Gendelman G., Ayzenberg O., Smirin N., Lysyansky P., Edri O. et al. Differential effects of coronary artery stenosis on myocardial function: the value of myocardial strain analysis for the detection of coronary artery disease. J. Am. Soc. Echocardiogr. 2011; 24 (7): 748–57. DOI: 10.1016/j.echo.2011.03.007
  17. Geyer H., Caracciolo G., Abe H., Wilansky S., Carerj S., Gentile F. Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications. J. Am. Soc. Echocardiogr. 2010; 23 (4): 351–69. DOI: 10.1016/j.echo.2010.02.015
  18. Park Y.H., Kang S.J., Song J.K., Lee E.Y., Song J.M., Kang D.H. et al. Prognostic value of longitudinal strain after primary reperfusion therapy in patients with anterior- wall acute myocardial infarction. J. Am. Soc. Echocardiogr. 2008; 21 (3): 262–7. DOI: 10.1016/j.echo.2007.08.026
  19. Delgado V., Mollema S.A., Ypenburg C., Tops L.F., van der Wall E.E., Schalij M.J. et al. Relation between global left ventricular longitudinal strain assessed with novel automated function imaging and biplane left ventricular ejection fraction in patients with coronary artery disease. J. Am. Soc. Echocardiogr. 2008; 21 (11): 1244–50. DOI: 10.1016/j.echo.2008.08.010
  20. Bijnens B.H., Cikes M., Claus P., Sutherland G.R. Velocity and deformation imaging for the assessment of myocardial dysfunction. Eur. J. Echocardiogr. 2009; 10 (2): 216–26. DOI: 10.1093/ejechocard/jen323
  21. Bijnens B., Claus P., Weidemann F., Strotmann J., Sutherland G.R. Investigating cardiac function using motion and deformation analysis in the setting of coronary artery disease. Circulation. 2007; 116 (21): 2453–64. DOI: 10.1161/CIRCULATIONAHA.106.684357
  22. Turschner O., D'Hooge J., Dommke C., Claus P., Verbeken E., De Scheerder I. et al. The sequential changes in myocardial thickness and thickening which occur during acute transmural infarction, infarct reperfusion and the resultant expression of reperfusion injury. Eur. Heart J. 2004; 25 (9): 794–803. DOI: 10.1016/j.ehj.2004.01.006
  23. Petersen J.W., Nazir T.F., Lee L., Garvan C.S., Karimi A. Speckle tracking echocardiography-determined measures of global and regional left ventricular function correlate with functional capacity in patients with and without preserved ejection fraction. Cardiovasc. Ultrasound. 2013; 11: 20. DOI: 10.1186/1476-7120-11-20
  24. Алехин М.Н. Ультразвуковые методы оценки де- формации миокарда и их клиническое значение. М.: Видар-М; 2012. [Alekhin M.N. Ultrasonic methods of evaluation of myocardial deformation and their clinical significance. Moscow: Vidar-M; 2012 (in Russ.).]
  25. Cho G.Y., Marwick T.H., Kim H.S., Hong K.S., Oh D.J. Global 2-dimention strain as a new prognosticator in patients with heart failure. J. Am. Coll. Cardiol. 2009; 54 (7): 618–24. DOI: 10.1016/j.jacc.2009.04.061
  26. Roes S.D., Mollema S.A., Lamb H.J., van der Wall E.E., de Roos A., Bax J.J. Validation of echocardiographic two-dimensional speckle tracking longitudinal strain imaging for viability assessment in patients with chronic ischemic left ventricular dysfunction and comparison with contrast-enhanced magnetic resonance imaging. Am. J. Cardiol. 2009; 104 (3): 312–7. DOI: 10.1016/j.amjcard.2009.03.040
  27. Lipiec P., Szymczyk E., Michalski B., Stefańczyk L., Wońniakowski B., Rotkiewicz A. et al. Echocardiographic quantitative analysis of resting myocardial function for the assessment of viability after myocardial infarction – comparison with magnetic resonance imaging. Kardiol. Pol. 2011; 69 (9): 915–22. PMID: 21928199
  28. Hutyra M., Skala T., Kaminek M., Horak D., Kocher M., Tudos Z. et al. Speckle tracking echocardiography derived systolic longitudinal strain is better than rest single photon emission tomography perfusion imaging for nonviable myocardium identification? Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech. Repub. 2013; 157 (1): 12–21. DOI: 10.5507/bp.2012.072
  29. Christenson J.T., Maurice J., Simonet F., Bloch A., Fournet P.C., Velebit V. et al. Effect of low left ventricular ejection fractions on the outcome of primary coronary bypass grafting in end stage coronary artery disease. J. Cardiovasc. Surg. 1995; 36 (1): 45–51. PMID: 7721925
  30. Tarakji K.G., Brunken R., McCarthy P.M., Al-Chekakie M.O., Abdel-Latif A., Pothier C.E. et al. Myocardial viability testing and the effect of early intervention in patients with advanced left ventricular systolic dysfunction. Circulation. 2006; 113 (2): 230–7. DOI: 10.1161/CIRCULATIONAHA.105.541664
  31. Samady H., Elefteriades J.A., Abbott B.G., Mattera J.A., McPherson C.A., Wackers F.J. Failure to improve left ventricular function after coronary revascularization for ischemic cardiomyopathy is not associated with worse outcome. Circulation. 1999; 100 (12): 1298–304. PMID: 10491374
  32. Franciosa J.A., Park M., Levine T.B. Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure. Am. J. Cardiol. 1981; 47 (1): 33–9. DOI: 10.1016/0002-9149(81)90286-1
  33. Carell E.S., Murali S., Schulman D.S., Estrada-Quintero T., Uretsky B.F. Maximal exercise tolerance in chronic congestive heart failure. Relationship to resting left ventricular function. Chest. 1994; 106 (6): 1746–52. DOI: 10.1378/chest.106.6.1746
  34. Filsoufi F., Jouan J., Chilkwe J., Rahmanian P.R., Castillo J., Carpentier A.F. et al. Results and predictors of early and late outcome of coronary artery bypass graft surgery in patients with ejection fraction less than 20%. Arch. Cardiovasc. Dis. 2008; 101 (9): 547–56. DOI: 10.1016/j.acvd.2008.09.008
  35. Fabiani I., Pugliese N.R., Santini V., Conte L., Di Bello V. Speckle-tracking imaging, principles and clinical applications: a review for clinical cardiologists. In: Lakshmanadoss U. (Ed.) Echocardiography in heart failure and cardiac electrophysiology. Ch. 5. InTech; 2016. DOI: 10.5772/64261
  36. Blessberger H., Binder T. Two dimensional speckle tracking echocardiography: clinical applications. Heart. 2010; 96 (24): 2032–40. DOI: 10.1136/hrt.2010.199885
  37. Мурашова Н.К. Возможности Speckle Tracking эхокардиографии в выявлении жизнеспособного миокарда у больных с хронической ишемической болезнью сердца: Автореф. дис. … канд. мед. наук. М.; 2014. [Murashova N.K. Facilities Speckle Tracking echocardiography in the detection of viable myocardium in patients with chronic ischemic heart disease. Cand. Med. Sc. Diss. Moscow; 2014 (in Russ.).]
  38. Суханов С.Г., Орехова Е.Н., Науменко И.Е., Матановская Т.В. Динамика продольной систолической деформации и симптомов хронической сердечной недостаточности у пациентов до и после хирургической реваскуляризации в сочетании с коррекцией ишемической митральной недостаточности. Патология кровообращения и кардиохирургия. 2015; 19 (1): 43–50. [Sukhanov S.G., Orekhova E.N., Naumenko I.E., Matanovskaya T.V. Systolic longitudinal strain congestive heart failure in patients with moderate ischemic mitral insufficiency before and after surgical revascularization and mitral annuloplasty. Patologiya Krovoobrashcheniya i Kardiokhirurgiya (Circulation Pathology and Cardiac Surgery). 2015; 19 (1): 43–50 (in Russ.).]

About Authors

  • Brand Yakov Beniaminovich, Dr. Med. Sc., Professor, Head of Department of Urgent Coronary Surgery; orcid.org/0000-0002-2188-041X
  • Bikbova Natal'ya Marsovna, Researcher, Ultrasonic Diagnostics Physician; orcid.org/0000-0002-3037-3292
  • Klyuchnikov Ivan Vyacheslavovich, Dr. Med. Sc., Professor, Chief Researcher; orcid.org/0000-0002-8652-9639
  • Kharitonova Nadezhda Ivanovna, Cand. Med. Sc., Senior Researcher; orcid.org/0000-0002-2249-8925
  • Mazanov Murat Khamidbievich, Cand. Med. Sc., Senior Researcher; orcid.org/0000-0003-4145-1337
  • Sagirov Marat Anvarovich, Cand. Med. Sc., Head of Department of Urgent Coronary Surgery; orcid.org/0000-0002-2971-9188
  • Ivanov Mikhail Grigor'evich, Junior Researcher; orcid.org/0000-0002-9692-0703

 If you found mistakes, select text and press Alt+A