Clinical Physiology of Circulation

ISSN 1814-6910 (Print)
ISSN 2410-9134 (Online)

 

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Issue's catalogue ➤ КФК. 2020; 17 (4): 241-328 ➤ Патофизиологические аспекты коморбидности факторов риска атеросклероза и саркопении

Pathophysiological aspects of comorbidity of risk factors of atherosclerosis and sarcopenia

Authors: Masenko V.L., Kokov A.N., Semenov S.E., Krivoshapova K.E., Barbarash O.L.

Company:
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2020-17-4-245-256

UDC: 616.13-004.6+616-092

Link: Clinical Physiology of Blood Circulaiton. 2020; 4 (17): 245-256

Quote as: Masenko V.L., Kokov A.N., Semenov S.E., Krivoshapova K.E., Barbarash O.L. Pathophysiological aspects of comorbidity of risk factors of atherosclerosis and sarcopenia. Clinical Physiology of Circulation. 2020; 17 (4): 245–56 (in Russ.). DOI: 10.24022/1814-6910-2020-17-4-245-256

Keywords:  atherosclerosis sarcopenia risk factors comorbidity

Received / Accepted:  25.06.2020 / 10.07.2020

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Abstract

Cardiovascular diseases (CVD) with a progressive course of atherosclerosis in elderly patients are aggravated by agerelated conditions, one of which is sarcopenia – a progressive decrease in the quantity and quality of striated muscles. The study of sarcopenia in patients with CVD causes a discussion in the scientific community regarding the general pathogenesis of atherosclerotic lesions and progressive loss of muscle mass from the position of concomitant pathology. This review analyzes the main modifiable risk factors for atherosclerosis and sarcopenia from in terms of pathophysiological mechanisms of their influence on the arterial bed and muscle tissue. We reviewed historical aspects and modern research devoted to the study of common links of atherogenesis and proteolysis. It is established that the risk factors considered in this review, such as smoking, obesity, impaired carbohydrate metabolism, and arterial hypertension, certainly have independent pathogenetic ways of implementing adverse effects, but the only link for them is the inflammatory response that determining the mutual potentiation and comorbidity of sarcopenia and atherosclerosis.

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****
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About Authors

  • Vladislava L. Masenko, Cand. Med. Sc., Researcher; ORCID
  • Aleksandr N. Kokov, Cand. Med. Sc., Head of Laboratory; ORCID
  • Stanislav E. Semenov, Dr. Med. Sc., Leading Researcher; ORCID
  • Kristina E. Krivoshapova, Cand. Med. Sc., Researcher; ORCID
  • Ol’ga L. Barbarash, Dr. Med. Sc., Professor, Corresponding Member of Russian Academy of Sciences, Director; ORCID

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