Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, Director of Bakoulev National Medical Research Center for Cardiovascular Surgery

The functional role of microvesicles in norm and pathology

Authors: S.V. Ignat’ev, A.V. Lyanguzov

Company:
Kirov Research Institute of Hematology and Blood Transfusion under the Federal Medical Biological Agency, ul. Krasnoarmeyskaya, 72, Kirov, 610027, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-69102019-16-4-261-266

UDC: 576.3:616-091.811

Link: Clinical Physiology of Blood Circulaiton. 2019; 16 (4): 261-266

Quote as: Ignat’ev S.V., Lyanguzov A.V. The functional role of microvesicles in norm and pathology. Clinical Physiology of Circulation. 2019; 16 (4): 261–6 (in Russ.). DOI: 10.24022/1814-6910-2019-16-4-261-266

Received / Accepted:  27.09.2019/14.10.2019

Full text:  

Abstract

Microvesicles are one of the types of extracellular vesicles that are released by cells and are found in all biological fluids and human tissues. Microvesicles may include RNA, free fatty acids, surface receptors, and proteins, thereby providing cellular and tissue homeostasis. At the same time, they are involved in the pathogenesis of some severe disorders, such as bleeding and thrombosis. Literature data are presented on the mechanisms of microvesicles formation, their composition and pathogenetic role in the development of diseases and complications of both thrombotic and hemorrhagic nature, as well as the possibility of using microvesiculation in clinical practice.

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About Authors

  • Sergey V. Ignat’ev, Cand. Med. Sc., Senior Researcher; orcid.org/0000-0002-8457-2967
  • Aleksey V. Lyanguzov, Cand. Med. Sc., Senior Researcher; orcid.org/0000-0001-5509-5308

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