Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Perioperative antithrombin activity in patients with coronary heart diseasecombined with pathology of the mitral valve

Authors: M.M. Rybka, E.A. Rogal'skaya, B.V. Meshchanov, N.N. Samsonova, L.G. Klimovich, D.Ya. Khinchagov, L.V. Chegrina, E.O. Esayan

Company:
Bakoulev National Scientific and Practical Center for Cardiovascular Surgery, Ministry of Health of the Russia, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

E-mail: Сведения доступны для зарегистрированных пользователей.

DOI: https://doi.org/10.24022/1814-6910-2017-14-2-91-95

UDC: 616.12-004.5:616.126.42-007.2:616.15.55-089

Link: Clinical Physiology of Blood Circulaiton. 2017; 14 (2): 91-95

Quote as: Rybka M.M., Rogal'skaya E.A., Meshchanov B.V., Samsonova N.N., Klimovich L.G., Khinchagov D.Ya., Chegrina L.V., Esayan E.O. Perioperative antithrombin activity in patients with coronary heart disease combined with pathology of the mitral valve. Klinicheskaya Fiziologiya Krovoobrashcheniya (Clinical Physiology of Circulation, Russian journal). 2017; 14 (2): 91–5 (in Russ.). DOI: 10.24022/1814-6910-2017-14-2-91-95

Received / Accepted:  14.02.2017/17.02.2017

Full text:  

Abstract

Objective: evaluation of antithrombin activity in patients with coronary heart disease in combination with mitral valve pathology at various stages of surgical intervention.
Material and methods. The study included 25 adult patients who underwent surgery on the mitral valve in combination with myocardial revascularization (coronary artery bypass grafting). Measurement of the test markers was conducted in two stages – before skin incision and after the closure of the surgical wound.
Results. An antithrombin activity before the operation was at 78 (69; 105) % and was not differ between patients with acute and chronic disorders of the mitral valve – 72 (67; 86) % and 86 (72; 112) %, respectively (p = 0.23). The second phase of the study revealed a statistically significant decrease in anti-thrombin activity – 59 (49; 72) % and 48 (44; 60) %, respectively, more significant in patients with chronic mitral valve impairment (16% vs 44%, p = 0,01).
Conclusion. Patients with an impairment of mitral valve in conjunction with coronary artery disease have initially reduced level of antithrombin, which is further reduced in the surgical correction of the heart disease. This effect is more pronounced in patients with long-existing defect of the mitral valve. This category of patients needs in antithrombin activity monitoring and, if necessary, its correction for the prevention of thrombosis and rationalization of heparin thetapy in the early postoperative period.

References

1. Кузник Б.И. Клеточные и молекулярные механиз-
мы регуляции системы гемостаза в норме и патоло-
гии. Чита: Экспресс-издательство; 2010: 191.
2. Fukuda Y., Kuroiwa Y., Okumiya K., Kuroiwa N.,
Ohshige T., Tabuchi H. et al. Hypercoagulability in
patients with mitral stenosis – from the viewpoint of
the behavior of plasma antithrombin III and alpha2-
plasmin inhibitor. Jpn Circ. J. 1980; 44 (11):
867–74.
3. Prihirunkit K., Sastravaha A., Lekcharoensuk C.,
Chanloinapha P. Hemostatic markers in congestive
heart failure dogs with mitral valve disease. J. Vet.
Med. 2014. DOI: 10.1155/2014/589873. Available at:
https://www.ncbi.nlm.nih.gov/pubmed/?term=
Hemostatic+Markers+in+Congestive+Heart+Failure+
Dogs+with+Mitral+Valve+Disease
4. Бокерия Л.А., Гудкова Р.Г. Сердечно-сосудистая
хирургия – 2015. Болезни и врожденные ано-
малии системы кровообращения. М.: НЦССХ
им. А.Н. Бакулева; 2016: 19.
5. Ланг Т.А., Сесик М. Как описывать статистику в
медицине: Руководство для авторов, редакторов,
рецензентов. М.: Практическая медицина; 2011:
70.
6. Clinical Chemistry Guide to Scientific Writing.
Available at: https://www.aacc.org/publications/
clinicalchemistry/clinicalchemistry%C2%A0guideto-
scientific-writing
7. Wiedermann C.J. Clinical review: molecular mechanisms
underlying the role of antithrombin in sepsis.
Crit. Care. 2006; 10 (1): 209.

About Authors

  • Rybka Mikhail Mikhaylovich, MD, PhD, DSc, Chief of Department of Anesthesiology and Intensive Care;
  • Rogal'skaya Ekaterina Anatol'evna, Physician of Clinical Laboratory Diagnostics;
  • Meshchanov Bair Valer'evich, Anesthesiologist-Intensivist;
  • Samsonova Natal'ya Nikolaevna, MD, PhD, DSc, Professor, Chief of Department of Clinical Laboratory Diagnostics;
  • Klimovich Lyudmila Grigor'evna, Dr. in Biol. Sci., Chief Research Associate;
  • Khinchagov Dzhumber Yakovlevich, MD, PhD, Anesthesiologist-Intensivist;
  • Chegrina Lyubov' Vladimirovna, MD, PhD, Anesthesiologist-Intensivist;
  • Esayan Evgeniy Olegovich, Physician of Clinical Laboratory Diagnostics

 If you found mistakes, select text and press Alt+A