Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery

Perioperative antithrombin activity in patients with coronary heart diseasecombined with pathology of the mitral valve

Authors: M.M. Rybka, E.A. Rogal'skaya, B.V. Meshchanov, N.N. Samsonova, L.G. Klimovich, D.Ya. Khinchagov, L.V. Chegrina, E.O. Esayan

Bakoulev National Scientific and Practical Center for Cardiovascular Surgery, Ministry of Health of the Russia, Rublevskoe shosse, 135, Moscow, 121552, Russian Federation

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UDC: 616.12-004.5:616.126.42-007.2:616.15.55-089

Link: Clinical Physiology of Blood Circulaiton. 2017; 14 (2): 91-95

Quote as: Rybka M.M., Rogal'skaya E.A., Meshchanov B.V., Samsonova N.N., Klimovich L.G., Khinchagov D.Ya., Chegrina L.V., Esayan E.O. Perioperative antithrombin activity in patients with coronary heart disease combined with pathology of the mitral valve. Klinicheskaya Fiziologiya Krovoobrashcheniya (Clinical Physiology of Circulation, Russian journal). 2017; 14 (2): 91–5 (in Russ.). DOI: 10.24022/1814-6910-2017-14-2-91-95

Received / Accepted:  14.02.2017/17.02.2017

Full text:  


Objective: evaluation of antithrombin activity in patients with coronary heart disease in combination with mitral valve pathology at various stages of surgical intervention.
Material and methods. The study included 25 adult patients who underwent surgery on the mitral valve in combination with myocardial revascularization (coronary artery bypass grafting). Measurement of the test markers was conducted in two stages – before skin incision and after the closure of the surgical wound.
Results. An antithrombin activity before the operation was at 78 (69; 105) % and was not differ between patients with acute and chronic disorders of the mitral valve – 72 (67; 86) % and 86 (72; 112) %, respectively (p = 0.23). The second phase of the study revealed a statistically significant decrease in anti-thrombin activity – 59 (49; 72) % and 48 (44; 60) %, respectively, more significant in patients with chronic mitral valve impairment (16% vs 44%, p = 0,01).
Conclusion. Patients with an impairment of mitral valve in conjunction with coronary artery disease have initially reduced level of antithrombin, which is further reduced in the surgical correction of the heart disease. This effect is more pronounced in patients with long-existing defect of the mitral valve. This category of patients needs in antithrombin activity monitoring and, if necessary, its correction for the prevention of thrombosis and rationalization of heparin thetapy in the early postoperative period.


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About Authors

  • Rybka Mikhail Mikhaylovich, MD, PhD, DSc, Chief of Department of Anesthesiology and Intensive Care;
  • Rogal'skaya Ekaterina Anatol'evna, Physician of Clinical Laboratory Diagnostics;
  • Meshchanov Bair Valer'evich, Anesthesiologist-Intensivist;
  • Samsonova Natal'ya Nikolaevna, MD, PhD, DSc, Professor, Chief of Department of Clinical Laboratory Diagnostics;
  • Klimovich Lyudmila Grigor'evna, Dr. in Biol. Sci., Chief Research Associate;
  • Khinchagov Dzhumber Yakovlevich, MD, PhD, Anesthesiologist-Intensivist;
  • Chegrina Lyubov' Vladimirovna, MD, PhD, Anesthesiologist-Intensivist;
  • Esayan Evgeniy Olegovich, Physician of Clinical Laboratory Diagnostics

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