Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Genetic risk factors forthrombophilias

Authors: Bockeria L. A., Bockeria O. L., Samsonova N. N., Lyadov K. V., Lemaeva I. V.

Link: Clinical Physiology of Blood Circulaiton. 2008; (): -

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Abstract

Polymorphisms of thrombus formation candidate genes were studied in 60 patients admitted with leg vein thrombosis. The control group included 25 people of comparable age without any thrombotic events in history. According to the prospective study results, we observed the greatest number of hetero- homozygous mutations in genes of apolipoprotein C III (45%), inhibitor of plasminogen activator (70%), fibrinogen (43.3%), methylentetrahydropholatreductase (48.3%). Statistically significant connections between vein thrombosis and hetero- homozygous mutations in genes of apolipoprotein C III, fibrinogen and inhibitor of plasminogen activator were revealed. A strong connection between phlebothrombosis development and carriage of normal variant of subitems of thrombocyte receptors GP IIb/IIIa gene was observed.

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