Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery

Ischemic mitralregurgitation and mitral valve deformation inpatients with acute myocardial infarction

Authors: Zhelnov V. V., Komarova I. S., Scheglova Yu. M., Andreeva N. V., Dvoretsky L. I.

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Link: Clinical Physiology of Blood Circulaiton. 2008; (): -

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A study was made to estimate the quantative data of mitral regurgitation in 152 patients with acute myocardial infarction (AMI) and ischemic mitral regurgitation (IMR) using two quantative techniques - the proximal isovelocity surface area method (PISA-method) and quantative Doppler technique using mitral and aortic stroke volumes (Q-DE- method). 52 of these patients were assessed based on a character of mitral deformation. Depending on the amount of mitral regurgitation four degrees of IMR severity were defined in patients with AMI and IMR. The area of effective regurgitate orifice (ERO), regurgitation fraction, and regurgitation volume in these patients allowed us to precisely define the severity of mitral regurgitation. Mitral regurgitation develops in AMI patients due to the mitral valve (MV) deformation. Assessing the degree of papillary muscle apical dislocation, the height and area of systolic apical flexure of MV cusps, and the degree of annular contraction allow us to estimate the character of MV deformation and predict the severity of IMR. The benefit from such approach is determined on the one hand by the simplicity of practical application and engineering feasibility, and on the other hand by the opportunity to diagnose the critical alterations of the mitral valve in patients with AMI and IMR.


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