Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Динамика нейробиохимических маркеров у больных во время коронарного шунтирования в условиях нормотермии и тепловой кровяной кардиоплегии

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Link: Clinical Physiology of Blood Circulaiton. 2010; (): -

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Abstract

Improvement of serum concentration of neurobiochemical markers - neurospecific enolase (NSE) and glial fibrillary acid protein (GFAP) - in 54 patients with ischemic heart disease (IHD), operated on in the Bakulev Scientific Center RAMS was studied. The first group included 28 patients who had chemical hypothermic cardiopulmonary bypass (HCPB) cardioplegia with Custodiol. The second group included 26 patients who had normothermal CPB (NCPB) combined with warm blood cardioplegia. All the patients had uncomplicated course of anesthetic and surgical process without signs of microembolization and cerebral hypoxia. Immediate perfusion effect on cerebral tissue damage rate and subsequent development of postoperative cerebral neurological complications depending on temperature rate was studied. It was established that under hypothermal CPB neurobiochemical markers rate of cerebral tissue damages increase by 1.4 -1.7 as compared to basic values and under normothermic CPB remain in the limits of basic values. Thus according to the data of normothermic CPB neurobiochemical markers rate the degree of cerebral tissue damages is minimal and therein this type of CPB has significant advantages compared to hypothermal.

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