Clinical Physiology of Circulation

Chief Editor

Leo A. Bockeria, MD, PhD, DSc, Professor, Academician of Russian Academy of Sciences, President of Bakoulev National Medical Research Center for Cardiovascular Surgery


Lipopolysaccharide-binding protein: main functions and clinical value

Authors: D.Sh. Samuilova, U.L. Borovkova

Company:
Samuilova Daniya Shavketovna, Dr. of Biol., Chief of clinical biochemistry laboratory;
Borovkova Ul'yana Leonidovna, physician clinical laboratory diagnostics

E-mail: Сведения доступны для зарегистрированных пользователей.

Link: Clinical Physiology of Blood Circulaiton. 2013; (): -

Full text:  

Abstract

Lipopolysaccharide-binding protein is constitutively present in blood of a healthy person, it is synthesized chiefly by hepatocytes. The key function of lipopolysaccharide-binding protein is to detect, bind and sequentially present bacterial endotoxin to geneticallyencoded receptors which are present on leukocytes and other cells, and that provide increased sensitivity of receptors to pathogen and amplification of signal of infection risk. Lipopolysaccharide-binding protein is able to detect molecular structures of gram-negative and gram-positive microorganisms and fungal pathogens. Current literature data provide evidence on the use of lipopolysaccharide-binding protein as a diagnostic biomarker of endotoxemia associated with local and severe infections in cardiac surgery patients. The article emphasizes its advantage compared to more commonly used markers of infection. However, the existing literature provides limited amount of research data on the clinical value of lipopolysaccharide-binding protein.

References

1. Ленгелер Й., Древс Г., Шлегель Г. (ред.). Cовременная микробиология. Прокариоты. Пер. с англ. И.В. Алферовой, А.В. Лебединского, К.Л. Тарасова. Нетрусов А.И. (ред.). Т. 2. М.: Мир; 2005. 2. Ma T.Y., Hollander D., Dadufalza V., Krugliac P. Effect of aging and caloric restriction on intestinal permeability. Exp. Gerontol. 1992: 27: 321–33. 3. Чахава О.В., Горская Е.М., Рубан С.З. Микробиологические и иммунологические основы гнотобиологии. М.: Медицина; 1982. 4. Kudlova M., Kunes P., Kolackova M. et al. Lipopolysaccharide-Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery. Mediators Inflamm. 2007; 2007. 72356: 1–6. 5. Yaroustovsky M., Plyushch M., Popov D. et al. Prognostic value of endotoxin activity assay in patients with severe sepsis after cardiac surgery. J. Inflamm. (Lond). 2013; 10 (1): 8. 6. Klein D.J., Briet F., Nisenbaum R. et al. Endotoxemia related to cardiopulmonary bypass is assoсiated with increased risk of infection after cardiac surgery: a prospective observational study. Crit. Care. 2011; 15 (1): R69. 7. Hanssen S.J., Libbers N., Hodin C.V. et al. Hemolysis results in impaired intestinal microcirculation and intestinal epithelial cell inyury. World J. Gastroenterol. 2011;17 (2): 213–8. 8. Beutler B.A. TLRS and innate immunity. Blood. 2009; 113: 1399–1407. 9. Matot I., Sprung C.C. Definition of sepsis. Intensive Care Med. 2001; 27 (1): S 3–9. 10. Opal S.M. Endotoxins and other sepsis triggers. Contrib. Nephrol. 2010; 167: 14–24. 11. Medzhitov R., Janeway C. Innate immunity. Engl. J. Med. 2000; 343: 338–44. 12. Prohinar P., Re F., Widstrom R. et al. Specific high affinity interactions of monomeric endotoxin protein complexes with Toll-like receptor 4 ectodomain. J. Biol. Chem. 2007; 282: 1010–7. 13. Schumann R.R. Old and new on lipopolysaccharide-binding protein: a soluble pattern-recognition molecule. Biochem. Soc. Trans. 2011; 39 (4): 989–93. 14. Lu Y.C., Yen W.C., Ohashi P.S. LPS/TLR4 signal transduction patway. Cytokine. 2008; 42: 145–51. 15. Post D.M., Zhang D., Eastvold J.S. et al. Biochemical and functional characterization of membrane, lebs purifield fr om Neisseria meningitides serogroup B. J. Biol. Chem. 2005; 280 (46): 38383–94. 16. Zweigner J., Schumann R.R., Weber J.R. The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes and Infection. 2006; 8 (3): 946–52. 17. Fitzgerald K.A., Rowe D.C., Golenbock D.T. Endotoxin recognition and signal transduction by the TLR4/MD2-cоmplex. Microbes. Infect. 2004; 6: 1361–7. 18. Kato A., Ogasawara T., Homma T. et al. Lipopolysaccharide-binding protein critically regulates lipipolysaccharide induced INF-beta signaling pathway in human monocytes. J. Immunol. 2004; 172: 6185–94. 19. Triantafilou M., Triantafilou K. Lipipolysaccharide recognition: CD14, TLRs and the LPS activation cluster. Trends Immunol. 2002; 23: 301–4. 20. Takeuchi O., Akira S. Pattern recognition receptors and inflammation. Cell. 2010; 140: 805–20. 21. Gonzalez-Quintela A., Alonso M., Campos J. et al. Determinants of serum concentrations of Lipopolysaccharide-Binding Protein (LBP) in the adult population: the role obesity. PLOS ONE. 2013; 8 (1): e54600. 22. Schröder N.W.J., Morath S., Alexander C. et al. Lipoteichoic acid (LTA) of Streptococcus pneumonia and Staphylococcus aureus cctivates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP) and CD14, wh ereas TLR-4 and MD-2 are not involved. J. Biol. Chem. 2003; 278: 15578–94. 23. Stehle J.R., Leng X., Kitzman D.W. et al. Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, in assotiated with physical function in healtly oder adults. J. Gerontol. A Biol. Sci. Med. Sci. 2012; 67 (11): 1212–8. 24. Pavare J., Grope I., Kalnins I., Gardovska D. High-mobility group box-1 protein, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in children with community acquired infections and bacteraemia: a prospective study. BMC Infect. Dis. 2010; 10: 28. 25. Volmer T., Piper C., Kleesiek K., Dreier J. Lipopolysaccharide-binding protein: a new biomarker for infectious Endocarditis? Clinical Chemistry. 2009; 55 (2): 295–304. 26. Villar J., Pérez-Méndez L. et al. Serum lipopolysaccharide-binding protein levels predict severety og lung injury and mortality in patients with severe sepsis. PLOS ONE. 2009; 4 (8): e6818. 27. Gaini S., Koldkjaer O.G., Pedersen C., Pedersen S.S. Procalcitonin, lipopoplysaccharide-binding protein, interleu-kin-6 and C-reactive protein in community- acquired infection and sepsis: a prospective study. Crit. Care. 2006; 10 (2): R53. 28. Mierzchala M., Krzystek-Korpacka M., Gamian A., Durek G. Quantitative indeces of dynamics in concentrations of lipopolysaccharide-binding protein (LBP) as prognostic factors in severe sepsis/septic shpck patients-comparison with CRP and procalcitonin. Clin. Biochem. 2011; 44 (5–6): 357–63. 29. Mussap M., Noto A., Fravega M., Fanos J. Soluble CD14 subtype presepsin (sCD14-ST) and lipopolysaccharide-binding protein (LBP) in nеоnatal sepsis: new clinical and analytical perspective for two biomarkers. J. Matern. Fetal Neonatal Med. 2011: 24 (2): 12–4. 30. Белобородова Н.В., Туманян М.Р., Черневская Е.А., Попов Д.А. и др. Современные биомаркеры инфекции в кардиохирургии новорожденных. Детские болезни сердца и сосудов. 2009; 1: 48–56. 31. Meynaar I.A., Droog W., Batstra M. et al. In critically ill patients, serum procalcitonin is more useful in differentiating between sepsis and SIRS than CRP, IL-6 or LBP. Crit. Care Res. Pract. 2011; 2011: 594645.

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